Insolubility and redistribution of GPI-anchored proteins at the cell surface after detergent treatment.
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چکیده
منابع مشابه
Insolubility and redistribution of GPI-anchored proteins at the cell surface after detergent treatment.
A diverse set of cell surface eukaryotic proteins including receptors, enzymes, and adhesion molecules have a glycosylphosphoinositol-lipid (GPI) modification at the carboxy-terminal end that serves as their sole means of membrane anchoring. These GPI-anchored proteins are poorly solubilized in nonionic detergent such as Triton X-100. In addition these detergent-insoluble complexes from plasma ...
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Glypicans are heparan sulfate proteoglycans that are attached to the cell surface by a GPI (glycosylphosphatidylinositol)anchor. Glypicans regulate the activity of Wnts, Hedgehogs,bone morphogenetic proteins and fibroblast growth factors. In the particular case of Wnts, it has been proposed that GPI-anchored glypicans stimulate Wnt signalling by facilitating and/or stabilizing the interaction b...
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ژورنال
عنوان ژورنال: Molecular Biology of the Cell
سال: 1995
ISSN: 1059-1524,1939-4586
DOI: 10.1091/mbc.6.7.929